解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of addi...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2019.05.020
更新日期:2019-06-18 00:00:00
abstract::Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4+ T cells needed for germinal center...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2019.04.011
更新日期:2019-05-21 00:00:00
abstract::The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmu...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2019.03.022
更新日期:2019-04-16 00:00:00
abstract::Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. However, only half of asthma patients exhibit signs of an exacerba...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2019.03.018
更新日期:2019-04-16 00:00:00
abstract::The epidermal growth factor receptor ligand Amphiregulin has a well-documented role in the restoration of tissue homeostasis after injury; however, the mechanism by which Amphiregulin contributes to wound repair remains unknown. Here we show that Amphiregulin functioned by releasing bioactive transforming growth facto...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2019.01.008
更新日期:2019-03-19 00:00:00
abstract::Curing HIV infection has been impossible, with the exception of the "Berlin Patient." Martinez-Navio et al. (2019) in Miami herein present a rare monkey whose virus was controlled for >3 years after a single genetic intervention that led to persistent production of HIV-neutralizing antibodies in vivo. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2019.02.010
更新日期:2019-03-19 00:00:00
abstract::The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrN...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.12.024
更新日期:2019-02-19 00:00:00
abstract::Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specif...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.12.012
更新日期:2019-02-19 00:00:00
abstract::CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-mediated immunity, indicating complex effects of RA on Th specification and the ou...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.12.014
更新日期:2019-01-15 00:00:00
abstract::As long-lived post-mitotic cells, neurons employ unique strategies to resist pathogen infection while preserving cellular function. Here, using a murine model of Zika virus (ZIKV) infection, we identified an innate immune pathway that restricts ZIKV replication in neurons and is required for survival upon ZIKV infecti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.11.017
更新日期:2019-01-15 00:00:00
abstract::Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon. This review summarizes our current understanding of pDC biology, including transcriptional regulation, heterogeneity, role in antiviral ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2018.12.027
更新日期:2019-01-15 00:00:00
abstract::Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.10.011
更新日期:2018-12-18 00:00:00
abstract::In allergic patients, small amounts of allergen activate mast cells and trigger an immune cascade that can result in anaphylactic shock. In a recent issue of Science, Choi et al. (2018) show that dendritic cells sample the lumen of blood vessels and use microvesicles to trigger mast cell degranulation and anaphylaxis....
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.12.004
更新日期:2018-12-18 00:00:00
abstract::Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the functional role of TL1A is not known. Here, we found that adherent IBD-associ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.10.014
更新日期:2018-12-18 00:00:00
abstract::Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.11.005
更新日期:2018-11-20 00:00:00
abstract::Interleukin-2 (IL-2) and downstream transcription factor STAT5 are important for maintaining regulatory T (Treg) cell homeostasis and function. Treg cells can respond to low IL-2 levels, but the mechanisms of STAT5 activation during partial IL-2 deficiency remain uncertain. We identified the serine-threonine kinase Ms...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.10.010
更新日期:2018-11-20 00:00:00
abstract::Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.07.014
更新日期:2018-10-16 00:00:00
abstract::Tissue-resident mast cells are associated with many inflammatory and physiological processes. Although mast cells arise from the yolk sac, the exact ontogeny of adult mast cells remains unclear. Here we have investigated the hematopoietic origin of mast cells using fate-mapping systems. We have shown that early erythr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.09.023
更新日期:2018-10-16 00:00:00
abstract::Co-evolution with their bacterial hosts has led to viral countermeasures against CRISPR-mediated immunity. In a recent issue of Cell, Landsberger et al. (2018) and Borges et al. (2018) report that cooperation among bacteriophages and multiple infection events are necessary to overcome CRISPR immune responses. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.08.023
更新日期:2018-09-18 00:00:00
abstract::The NF-κB pathway plays a crucial role in supporting tumor initiation, progression, and radioresistance of tumor cells. However, the role of the NF-κB pathway in radiation-induced anti-tumor host immunity remains unclear. Here we demonstrated that inhibiting the canonical NF-κB pathway dampened the therapeutic effect ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.07.008
更新日期:2018-09-18 00:00:00
abstract::HIV-1 Envelope (Env) mediates viral-host membrane fusion after binding host-receptor CD4 and coreceptor. Soluble envelopes (SOSIPs), designed to mimic prefusion conformational states of virion-bound envelopes, are proposed immunogens for eliciting neutralizing antibodies, yet only static structures are available. To e...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.06.017
更新日期:2018-08-21 00:00:00
abstract::In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.08.009
更新日期:2018-08-21 00:00:00
abstract::Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and re...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.07.001
更新日期:2018-07-17 00:00:00
abstract::Memory T cells provide long-lasting protective immunity, and distinct subpopulations of memory T cells drive chronic inflammatory diseases such as asthma. Asthma is a chronic allergic inflammatory disease with airway remodeling including fibrotic changes. The immunological mechanisms that induce airway fibrotic change...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.023
更新日期:2018-07-17 00:00:00
abstract::Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.05.015
更新日期:2018-06-19 00:00:00
abstract::PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.031
更新日期:2018-06-19 00:00:00
abstract::Despite the importance of Th17 cells in autoimmune diseases, it remains unclear how they control other inflammatory cells in autoimmune tissue damage. Using a model of spontaneous autoimmune arthritis, we showed that arthritogenic Th17 cells stimulated fibroblast-like synoviocytes via interleukin-17 (IL-17) to secrete...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.009
更新日期:2018-06-19 00:00:00
abstract::The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.013
更新日期:2018-06-19 00:00:00
abstract::In this issue of Immunity, Trompette et al. (2018) show that dietary fiber and short chain fatty acids reduce influenza A virus-associated immunopathology by enhancing CD8+ T cell effector function and by promoting the differentiation of alternatively activated macrophages. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.05.001
更新日期:2018-05-15 00:00:00
abstract::Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fer...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.022
更新日期:2018-05-15 00:00:00
abstract::We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-character...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.03.023
更新日期:2018-04-17 00:00:00
abstract::Chronic inflammatory diseases represent an increasing medical burden, yet neither tools to predict the individual disease course nor causal cures are at hand. We discuss opportunities for systems medicine to derive precise, individualized disease models and outline the European consortium SYSCID as part of the roadmap...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.03.022
更新日期:2018-04-17 00:00:00
abstract::Higher- or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC recycling, respectively; however, how commitment to the plasma cell fate takes place is unclear. We found that a population of light zone (LZ) GC cells, Bcl6loCD69hi expressing a transcription factor IRF4 and higher-affinit...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.03.027
更新日期:2018-04-17 00:00:00
abstract::Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.02.012
更新日期:2018-03-20 00:00:00
abstract::The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the d...
journal_title:Immunity
pub_type: 信件
doi:10.1016/j.immuni.2018.03.005
更新日期:2018-03-20 00:00:00
abstract::In this issue of Immunity, Mrdjen et al. (2018) use high-dimensional single-cell proteomics and high parametric mass cytometry to provide insight into the long-lasting issue of how to identify and characterize both resident and recruited leukocyte populations in healthy, aged, and diseased CNS. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.02.009
更新日期:2018-02-20 00:00:00
abstract::Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, the mechanisms by which IL-10 facilitates the establishment of chronic infection are not fully understood. Herein, we demonstrate...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.01.006
更新日期:2018-02-20 00:00:00
abstract::Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. We report that transient receptor potential melastatin-like 7 (TRPM7),...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.026
更新日期:2018-01-16 00:00:00
abstract::Acute hepatitis A (AHA) involves severe CD8+ T cell-mediated liver injury. Here we showed during AHA, CD8+ T cells specific to unrelated viruses became activated. Hepatitis A virus (HAV)-infected cells produced IL-15 that induced T cell receptor (TCR)-independent activation of memory CD8+ T cells. TCR-independent acti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.025
更新日期:2018-01-16 00:00:00
abstract::Mutant RAS is a major oncoprotein in human cancer and PD-L1 is a key driver of cancer immune evasion. In this issue of Immunity, Coelho et al. (2017) demonstrate that oncogenic RAS signaling promotes tumor immune escape by stabilizing PD-L1 mRNA. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.12.001
更新日期:2017-12-19 00:00:00